Is ghrelin a glucagon‐like peptide‐1 secretagogue?
نویسندگان
چکیده
منابع مشابه
Is ghrelin a glucagon‐like peptide‐1 secretagogue?
Ghrelin was reported to enhance GLP-1 secretion after glucose load in mice.
متن کاملGhrelin -- a new endogenous growth hormone secretagogue.
Ghrelin is a new endogenous peptide, discovered in 1999 by Kojima et al., as the result of a search for an endogenous ligand for an orphan receptor of known structure and function. Ghrelin is composed of 28 amino acids and is produced mostly by cells of the stomach, hypothalamus, and hypophysis, but it has also been detected in other tissues. Its discovery is related to the development of a new...
متن کاملGhrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.
Synthetic agonists of the growth hormone secretagogue receptor (GHSR) rejuvenate the pulsatile pattern of GH-release in the elderly, and increase lean but not fat mass in obese subjects. Screening of tissue extracts in a cell line engineered to overexpress the GHSR led to the identification of a natural agonist called ghrelin. Paradoxically, this hormone was linked to obesity. However, it had n...
متن کاملThe endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes.
Ghrelin, the endogenous ligand for the GH secretagogue receptor (GHS-R), is a recently isolated hormone, prevalently expressed in stomach but also in other tissues such as hypothalamus and placenta. This novel acylated peptide acts at a central level to stimulate GH secretion and, notably, to regulate food intake. However, the existence of further, as yet unknown, effects or presence of ghrelin...
متن کاملUnacylated ghrelin acts as a potent insulin secretagogue in glucose-stimulated conditions.
Acylated and unacylated ghrelin (AG and UAG) are gut hormones that exert pleiotropic actions, including regulation of insulin secretion and glucose metabolism. In this study, we investigated whether AG and UAG differentially regulate portal and systemic insulin levels after a glucose load. We studied the effects of the administration of AG (30 nmol/kg), UAG (3 and 30 nmol/kg), the ghrelin recep...
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ژورنال
عنوان ژورنال: Journal of Diabetes Investigation
سال: 2015
ISSN: 2040-1116,2040-1124
DOI: 10.1111/jdi.12431